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f , Left, volcano plot showing relative fold change (log 2 ) in whole cell metabolite abundance versus log 10 (P value) from KPK cells expressing a sgRNA targeting intergenic region or sgRNA targeting Slc33a1

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[13] [15] There is a risk of oxalate nephropathy or kidney stone formation, particularly in patients with pre-existing renal impairment or those receiving prolonged high-dose therapy